Scientist-Technologist Building Infrastructure for Tomorrow’s Discoveries

Over the past several years, I have worked at the intersection of instrument development, computational microscopy, and large-scale cellular structural biology.

Throughout this journey, I have developed methods and tools that are now widely used in the field, including TOMOMAN for large-scale cryo-ET preprocessing, STOPGAP for template matching and subtomogram averaging, and timely contributions to AI-driven approaches, such as cryoDRGN-ET, enabling deep generative modeling of conformational heterogeneity. In parallel with these computational advances, I have pushed experimental frontiers in cryo-FIB lamella preparation, multishot tomography for higher-throughput data acquisition, integration of new imaging modalities such as 4D-STEM, and detector technologies including Timepix4.

My work has led to several high-impact biological discoveries, including the in-cell architecture of the mitochondrial respiratory chain and the discovery of a spatial gradient in nucleolar ribosome biogenesis. Furthermore, I pioneered and coordinated a collaborative effort producing one of the largest open cryo-ET datasets (~1,800 tomograms of Chlamydomonas reinhardtii), advancing both methods development and biology through community-driven visual proteomics.

I am also committed to mentoring and teaching, with extensive experience instructing at an EMBO practical course and several others.

Altogether, I bring unique cross-disciplinary and cross-sectoral expertise with an established, long-standing network of leading academic and industry collaborations. Curious about how I got here? Read Tracing an Unconventional Path: My Journey in Science…So Far, a personal reflection on the winding path through physics, structural biology, cryo-electron tomography, and structural systems biology at scale leading to OPENEMAGE.

Learn more about the initiatives, explore methods and open datasets, or visit the teaching page for recent courses and mentoring activities.