Mapping The mRNA Life Cycle with Computational Microscopy

I am a computational microscopist exploring how molecular structure and cellular organization shape biological systems. My research focuses on decoding the mRNA life cycle as a spatially organized, structurally dynamic system, using cutting-edge methods including cellular cryo-electron tomography, advanced multimodal microscopy, and integrative computational analysis.

In my current role I bridge academic innovation with industry-driven technological development, advancing methodologies in cryo-electron tomography, 4D-STEM, cryoFIB-SEM, and next-generation cellular imaging.

I am now transitioning to an independent position by establishing the RNAcartography initiative. This initiative aims to map the mRNA lifecycle directly within cells by integrating visual proteomics, high-resolution imaging, and systems-level analysis. The initiative builds upon my foundational computational and experimental innovations; including multishot tomography, cryo-FIB milling optimizations, and quantitative subtomogram averaging and classification; which enabled insights into ribosome biogenesis, translational dynamics, and spatial organization.

Curious about how I got here? Read Tracing an Unconventional Path: My Journey in Science…So Far, a personal reflection on the winding path through physics, structural biology, cryo-electron tomography, and cell biology that shaped my scientific approach and led to RNAcartography.

Learn more about the initiatives, explore methods and open datasets, or visit the teaching page for recent courses and mentoring activities.